皮疹とワクチンとシェディングの論文

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Conclusions

In this brief review article, we demonstrated that unspecific injection-site reactions are most frequent following COVID-19 vaccination. Moreover, different type I and type hypersensitivity reactions, autoimmune-mediated skin findings, functional angiopathies and (re)activation of viral conditions may be associated with COVID-19 vaccination. Hence, there are numerous cutaneous reaction patterns that may occur following COVID-19 vaccination, whereby many of these skin findings are of immunological/autoimmunological nature (Fig. 6).7-67 It has been demonstrated that molecular mimicry exists between SARS-CoV-2 and human components (e.g. the spike-protein sequences used to design the vaccines) and may thus explain some COVID-19 pathologies as well adverse reactions to COVID-19 vaccinations.68 However, there are also uncertainties with regard to the question whether some of the previously reported skin complications after COVID-19 vaccination were really true or just coincident without causality. Even though the temporal relationship as well as experience with other vaccines may be suggestive for causality, the high prevalence of some conditions (e.g. herpes zoster) and the very large number of cases receiving COVID-19 vaccinations during the last months may result in bias including many cases in which the skin manifestations were not caused by the COVID-19 vaccination but developed spontaneously despite the temporal relationship. Moreover, Tan et al.69 recently demonstrated a significant discordance between morphological descriptions of cutaneous findings among countries. In line with Kantor,70 we are afraid that essentially all reports on cutaneous manifestations associated with COVID-19 may be biased, also including data obtained from large registries (e.g. VAERS) in which not only dermatologists report their patients’ skin findings.